The liver is essential for metabolism, blood glucose control, blood composition, immunity, and hemostasis of the entire organism. Notably, it is the only inner organ that can completely regenerate, as long as its cells are not damaged. The ability of the liver to regenerate declines when the liver stores more and more lipids (a state called hepatic steatosis). Steatotic liver diseases often occur during diabetes mellitus, and they (like diabetes) contribute to cardiovascular diseases. In our research, we study the molecular signals from blood vessels (called “angiokines”) that facilitate liver regeneration and are needed for cardiac health. We hope that the results from our research also open up new ways to regenerate other organs and provide targets to better treat hepatic and cardiovascular diseases.